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Split hand-split foot malformation

6 OMIM references -
5 associated genes
9 signs/symptoms

PROTEIN INTERACTIONS: 1

Meacham syndrome

1 OMIM reference -
1 associated gene
22 signs/symptoms

Split hand-split foot malformation

Meacham syndrome

BTRC	(UniProt - OMIM)		WT1	(UniProt - OMIM)
FBXW4	(UniProt - OMIM)
SHFM1	(UniProt - OMIM)
TP63	(UniProt - OMIM)
WNT10B	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	TP63	(0.55)	WT1

Citations in the biomedical literature:

Split hand-split foot malformation		Meacham syndrome
	Synonym(s): - Ectrodactyly - Lobster-claw deformity - SHFM - Split hand foot malformation		Synonym(s): - Meacham-Winn-Culler syndrome - Rhabdomyomatous dysplasia - cardiopathy - genital anomalies

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare gynecologic or obstetric disease - Rare urogenital disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 6 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Split hand-split foot malformation		Meacham syndrome
	Very frequent - Autosomal dominant inheritance - Oligodactyly / ectrodactyly of fingers Frequent - Syndactyly of fingers / interdigital palm Occasional - Aniridia / iris hypoplasia - Autosomal recessive inheritance - Hand agenesis / absence - Sensorineural deafness / hearing loss - Trident hand / split hand / abnormal median ray - X-linked recessive inheritance		Very frequent - Ambiguous genitalia - Diaphragmatic hernia / defect / agenesis - Hypoplastic lungs / pulmonary hypoplasia / agenesis - Uterine / uterus / Fallopian tubes anomalies - Vagina anomalies / atresia / hydrometrocolpos / hymen imperforation Frequent - Absent lobe / lung / segmentation defect / abnormal lobulation / sequestration - Death in infancy - Hypoplastic left heart / ventricle - Micropenis / small penis / agenesis - Stillbirth / neonatal death - Structural and functional anomalies of the spleen - Undescended / ectopic testes / cryptorchidia / unfixed testes Occasional - Anomalous pulmonary venous return - Asplenia / polysplenia / spleen lobulation / accessory spleen - Atrial septal defect / interauricular communication - Dextrocardia / abnormal heart position / cardiac heterotaxia / situs inversus - Ectopic / horseshoe / fused kidneys - Hypoplastic aorta / coarctation / stenosis / anomaly / aortic arch interruption - Patent ductus arteriosus - Tetralogy of Fallot / trilogy of Fallot - Transposition of great vessels - Ventricular septal defect / interventricular communication